Principal Scientist II, Cell & Gene Therapy Delivery

Company: Advanced Accelerator Applications (Italy) - S...
Location: San Diego
Posted on: October 22, 2024

Job Description:

Principal Scientist II, Cell & Gene Therapy DeliveryJob ID: REQ-10021278Date: Sep 10, 2024Location: USASummaryPosition is onsite in San Diego.Summary:INNOVATION, QUALITY, COLLABORATION, PERFORMANCE, COURAGE AND INTEGRITY.Novartis Biologics Center (BRC) builds the Novartis biologics pipeline in collaboration with Biomedical Research disease and functional area departments via a breadth of technologies for discovery of antibody, protein, cell and gene therapy-based therapeutics. The Cell and Gene Therapy (CGT) group within BRC drives a diverse portfolio of modalities including multi-specific antibodies, CAR-T, RNA therapeutics and AAV. Through cell and viral engineering as well as innovative and rational protein design, the CGT group is a global team that works collaboratively with disease area groups to broaden the use of biologics into therapeutic applications where conventional antibodies have limitations.As a Principal Scientist II part of the BRC CGT group in San Diego, CA, you will have a unique opportunity to be at the cutting edge of the cell and gene therapy field and lead and contribute to the development of innovative medicines for patients devastated by diseases in collaboration with partners across the global Novartis research and development network.About the RoleYour responsibilities will include, but are not limited to:

• Lead, oversee and/or participate in next-generation CGT delivery improvement projects across multiple Novartis sites to enable pipeline and platform advances and novel therapeutic capabilities in close collaboration with disease area leaders and global project teams.
• Undertake and lead efforts to develop more potent, safer and tolerable LVV and AAV vectors. The mechanisms in scope include, but are not limited to, improving tropism/targeting, reduction of immune response, spatial/temporal regulated expression control strategies, circuit engineering, transcriptional/post-transcriptional aspects and strategies for high throughput optimization of vector components.
• Enable translation from in vitro/in vivo mouse and nonhuman primate POC studies to therapeutic disease programs for preclinical development.
• Initiate, lead and contribute to interdisciplinary research programs in a highly collaborative and matrixed manner across internal groups and with external partners.
• Prepare reports, manuscripts and protocols, adhering to the good research practices and quality culture across NIBR. Present results at appropriate internal and external meetings and conferences.
• Other related duties as assigned.What you'll bring to the role:Requirements:
  • Bachelor's degree in cell and gene therapy, bioinformatics, molecular/cell biology, bioengineering, or related scientific field with 12 years industry or equivalent experience or Master's with degree in cell and gene therapy, bioinformatics, molecular/cell biology, bioengineering, or related scientific field with 10 years industry or equivalent experience or PhD with 6 years of industry or equivalent experience.
  • Successful track record in directly and in a matrix manner leading scientists and project team members with diverse backgrounds is required.
  • Demonstrated expertise in LVV and AAV biology, virology, viral tropism engineering, transcriptional and post-transcriptional mechanisms, and analytical/process development for LVV/AAV production is required.
  • The position requires the ability to work collaboratively across a dynamic and collaborative scientific and development environment. Therefore adaptability to emerging project/group needs, excellent communication skills, both written and verbal, and strong interpersonal skills are required.
  • Strong publication, patent and/or external presentation record.
  • Genetic/epigenomic/transcriptomic profiling technologies, genome engineering (e.g. CRISPR), nonviral gene therapy, sh/miRNA biology, and/or analytical/process development for LVV/AAV production are highly desired.Please note this job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee for this job. Duties, responsibilities and activities may change at any time with or without notice.Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other.Commitment to Diversity & Inclusion: The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status.Accessibility & Reasonable Accommodations: The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to us.reasonableaccommodations@novartis.com or call +1(877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.Division: Biomedical ResearchBusiness Unit: Pharma ResearchLocation: USASite: San DiegoCompany / Legal Entity: U175 (FCRS = US175) Novartis Institutes for BioMedical Research, Inc.
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Keywords: Advanced Accelerator Applications (Italy) - S..., National City , Principal Scientist II, Cell & Gene Therapy Delivery, Healthcare , San Diego, California